Practitioner formulated · 100% natural · Therapeutic doses · Fast global shipping
Butterworth Health
Optimise your NO

As you age, your nitric oxide declines

It's the molecule that protects your body as we age, yet it halves by age 40.

Optimise your NO
★★★★★ Formulated by Jeff Butterworth N.D. · 30 years in practice
The master molecule

Nitric oxide is the foundational molecule for HEALTH.

More nitric oxide means more blood, oxygen and energy reaching every part of you. 

Healthy open artery versus narrowed artery
Why it matters

One molecule. Hundreds of functions.

Heart

Healthy circulation & blood pressure

Energy

Oxygen to every muscle

Brain

Clarity & focus

Defence

Antioxidant & immune support

50%

Less nitric oxide by the time you're 40.

Healthy NO levels are foundational. All other supplements come second to optimising NO. Without healthy NO levels your body will never respond as you wish.

The science

As nitric oxide falls, disease takes over.

As nitric oxide falls, disease takes over — a timeline of degenerative conditions that emerge as nitric oxide declines
Backed by research

The evidence behind every claim.

Nitric oxide is one of the most studied molecules in medicine. Explore 60+ peer-reviewed studies across heart, brain, energy, immunity and more — with links to every paper.

Explore the science →
What low NO feels like

You've probably noticed already.

Low energy

Elevated BP and Cholesterol

Brain fog

Weight gain

Slow recovery

Low hormone production

The simple path

Test. Optimise. Support.

Three steps, one a day. Pick where you start — either way, you'll know your numbers.

Nitric Oxide Test Strips
Just curious
Step 1 · Test

Test Strips

A 15-second saliva strip shows where you stand.

$9.95 $29.95
  • Know your nitric oxide baseline
  • 15-second saliva test
  • Affordable one-time purchase
Buy strips
Ultimate 4 and test strips
Most popular
Step 2 · Optimise

Test Strips + Ultimate 4

One scoop daily rebuilds your nitric oxide.

$69.95 $99.95
  • 30 daily serves of Ultimate 4
  • Test strips to track your rise
  • Four NO pathways, therapeutic doses
Start optimising
Boost, Ultimate 4 and test strips
Best value
Step 3 · Support

Test Strips + Ultimate 4 + Boost

Add Boost to lock in long-term results.

$129.95 $159.95
  • Everything in Ultimate 4
  • Boost for daily support
  • The complete optimal protocol
Go optimal

Vegetarian · 100% natural · update or cancel anytime · fast global shipping

Ultimate 4 as part of a daily routine
Your daily ritual

One scoop. Every morning.

Mix it, drink it, get on with your day — and let the science work in the background.

Beetroot and arugula — nitrate-rich ingredients
What's inside

What's inside — and what it does.

No proprietary blends, no fillers, no synthetic vitamins or minerals. Just the building blocks your body uses to make and protect nitric oxide.

Standardised to 360 mg dietary nitrates, which generates 350–400 mg/L nitric oxide in the blood.

L-Citrulline
Fuels your body's own nitric oxide production
Beetroot extract
A nitrate-rich root that converts into nitric oxide
Arugula extract
One of nature's richest dietary nitrate sources
Vitamin C
Helps protect nitric oxide so more stays available
Taurine & Magnesium
Support healthy circulation and vascular relaxation
Hibiscus & Glycine
Antioxidant support for blood pressure and calm
Don't guess. Test.

The only NO formula you can measure.

Watch your saliva strip climb toward the optimal range as Ultimate 4 goes to work.

10–20 Low20–110 Moderate110–220 Good220–435 Excellent435+ High

Aim for 220–435 mg/L, sweet spot ≈ 350. Below 110? It's time to act.

Vibrant, healthy older man

Rediscover energy levels from your YOUTH.

Rebuild the one molecule you can actually bring back — and feel the difference.

From the community

People who tested, then felt it.

★★★★★

"I'd accepted feeling flat as getting older. Three weeks in, my strip jumped two whole bands. The energy is back."

David R.Verified customer
★★★★★

"Being able to measure it sold me. Watching my number climb toward 350 makes it feel real."

Mark T.Verified customer
★★★★★

"Proper doses, not a token sprinkle. My morning walk doesn't leave me winded anymore."

Geoff H.Verified customer

Individual results may vary. Reviews reflect personal experience.

Jeff Butterworth N.D. The Butterworth Method
"I built Ultimate 4 for myself — to fix the one change I saw in everyone after 40: declining nitric oxide. Real results, not hype."
Jeff Butterworth, N.D.Founder · 30 years in integrated health

Stop accepting the slow fade.

Test your level, optimise with Ultimate 4, and bring your nitric oxide back.

Optimise your NO
Ready to start?

Add to cart

Choose your option and check out securely.

Test Strips
Test Strips
Know your nitric oxide baseline
$9.95 $29.95
Add to cart
Test Strips + Ultimate 4
Test Strips + Ultimate 4 · Most popular
Test, then optimise your NO daily
$69.95 $99.95
Add to cart
Test Strips + Ultimate 4 + Boost
Test Strips + Ultimate 4 + Boost
The complete optimal protocol
$129.95 $159.95
Add to cart

Secure checkout · Vegetarian · 100% natural · update or cancel anytime · fast global shipping

Optimise your NO