Heart
Healthy circulation & blood pressure
It's the molecule that protects your body as we age, yet it halves by age 40.
THE MASTER MOLECULE
Nitric oxide is the foundational molecule for health.
More nitric oxide means more blood, oxygen and energy reaching every part of you.
50%
Less nitric oxide by the time you're 40.
Healthy NO levels are foundational. All other supplements come second to optimising NO. Without healthy NO levels your body will never respond as you wish.
WHY IT MATTERS
One molecule. Hundreds of functions.
Energy
Oxygen to every muscle
Brain
Clarity & focus
Defence
Antioxidant & immune support
THE SCIENCE
As nitric oxide falls, disease takes over.
BACKED BY RESEARCH
The science behind every claim
Nitric oxide is one of the most studied molecules in medicine. Explore 60+ peer-reviewed studies across heart, brain, energy, immunity and more, with links to every paper.
SIGNS YOUR LEVELS ARE LOW
Recognise these?
These are the everyday signs of declining nitric oxide, often written off as “just getting older.”
Cold hands and feet
Low stamina
Rising blood pressure
Brain fog
Slow recovery
Reduced drive
DON'T GUESS. TEST.
The only NO formula you can measure.
Watch your saliva strip climb toward the optimal range as Ultimate 4 goes to work.
10–20 Low20–110 Moderate110–220 Good220–435 Excellent435+ High
Aim for 220–435 mg/L, sweet spot ≈ 350. Below 110? It's time to act.
THE SIMPLE PATH
Test. Optimise. Support.
Three steps, one a day. Pick where you start. Either way, you'll know your numbers.
Step 1 · Test
Test Strips
A 15-second saliva strip shows where you stand.
$9.95$29.95
- Know your nitric oxide baseline
- A 15-second saliva test
- Affordable one-time purchase
Step 2 · Optimise
Test Strips + Ultimate 4
One scoop daily rebuilds your nitric oxide.
$69.95$99.95
- 30 daily serves of Ultimate 4
- Test strips to track your rise
- Four NO pathways, therapeutic doses
Step 3 · Support
Test Strips + Ultimate 4 + Boost
Add Boost to lock in long-term results.
$129.95$159.95
- Everything in Ultimate 4
- Boost for daily support
- The complete optimal protocol
Vegetarian · 100% natural · subscribe and cancel anytime · fast global shipping
REAL RESULTS
What people notice first.
“Within two weeks my hands weren't cold anymore. That was the first thing I noticed.”
Karen L. · Verified customer
“My blood pressure reading finally moved in the right direction. My doctor asked what I'd changed.”
Peter S. · Verified customer
“I can get through a full round of golf without running out of steam. Didn't expect that at 61.”
Alan R. · Verified customer
WHAT'S INSIDE
What's inside, and what it does.
No proprietary blends, no fillers, no synthetic vitamins or minerals. Just the building blocks your body uses to make and protect nitric oxide.
Standardised to 360 mg dietary nitrates, which generates 350–400 mg/L nitric oxide in the blood.
L-Citrulline
Fuels your body's own nitric oxide production
Beetroot extract
A nitrate-rich root that converts into nitric oxide
Arugula extract
One of nature's richest dietary nitrate sources
Vitamin C
Helps protect nitric oxide so more stays available
Taurine & Magnesium
Support healthy circulation and vascular relaxation
Hibiscus & Glycine
Antioxidant support for blood pressure and calm
One scoop. Every morning.
“Nitric oxide is the single most overlooked lever in ageing well. Fix it, and patients feel the difference within weeks — not months.”
Jeff Butterworth, N.D.
30 YEARS IN INTEGRATIVE HEALTH
N=O
Free course · New
Understand it yourself: The Nitric Oxide Academy
A free, self-paced course on the molecule behind your health, from Jeff Butterworth. Two tracks, chapter-by-chapter learning with quizzes, and a certificate of completion.
1
Nitric Oxide EssentialsThe foundation molecule, in plain English
2
Clinical & Biochemical MasterclassExhaustive, for medical professionals
Free · Certificate on completion
READY WHEN YOU ARE
Start optimising your nitric oxide today
Test your levels, start Ultimate 4, and feel the difference in weeks — not years.