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Practitioner Formulated
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Fast Global Shipping
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Practitioner Formulated
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100% Secure Checkout
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Fast Global Shipping
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Practitioner Formulated
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100% Secure Checkout
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Fast Global Shipping
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Practitioner Formulated
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100% Secure Checkout
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Practitioner formulatedBy Jeff Butterworth N.D, 30 years in practice
Therapeutic dosesAmounts that match the research
International shippingWe ship worldwide
Real people, real supportTake the assessment and join the community
Why nitric oxide
By 40, most adults make roughly half the nitric oxide they did at 20.
Nitric oxide relaxes and widens blood vessels so blood, oxygen and nutrients reach every cell. When it falls, circulation, blood pressure, stamina and recovery follow.
2Nitric oxide pathways supported in one daily scoop.
15 secTo check your levels at home with a saliva strip.
33Serves per jar. One scoop a day.
Lyons et al., Clinical Science 1997: lower nitric oxide production in healthy older adults.
How it works
Two pathways, protected.
Most nitric oxide products use one pathway. Ultimate 4 feeds both, then protects what you make with an antioxidant complex.
1
The arginine pathwayL-citrulline converts to arginine, then to nitric oxide inside the vessel wall.
2
The nitrate pathwayBeetroot and arugula nitrates convert to nitric oxide through the mouth and gut.
3
The protection layerVitamin C, glycine, taurine and hibiscus help the nitric oxide survive.
Full disclosure
Every ingredient, every dose.
No proprietary blends. Therapeutic amounts, per 6 g serve.
L-citrulline1,620 mgConverted to arginine and then to nitric oxide, the body's first pathway
Beetroot (20% nitrates)1,200 mgDietary nitrates for the second nitric oxide pathway
Arugula (10% nitrates)1,200 mgOne of the richest leafy sources of nitrates
Vitamin C600 mgAntioxidant that helps protect the nitric oxide you make
Glycine600 mgAmino acid that supports antioxidant defences
Taurine360 mgSupports healthy blood vessel function
Hibiscus216 mgAntioxidant-rich botanical
Magnesium taurate180 mgSupports normal muscle and vascular function
Silica24 mgSupports connective tissue
Why Ultimate 4 is different
Ultimate 4
Typical nitric oxide product
Nitric oxide pathways
✓Both
Usually one
Antioxidant protection
✓Built in
Rarely
Doses shown on the label
✓Every ingredient
Often hidden in blends
Way to check it's working
✓Saliva test strips
None
Formulated by
✓A naturopath, for his own use
A marketing team
If I could only take one supplement, it would be this.
Jeff Butterworth N.DSpecialist Naturopath, 30 years in clinical practice
Jeff created Ultimate 4 for his own daily routine after a heart scan changed how he thought about ageing.
Test, take, retest
1Day 1Test your baseline with a saliva strip
2Week 1One scoop every morning or before exercise
3Weeks 2 to 4Retest. Most people see the colour deepen
4OngoingKeep your levels in the optimal range
Individual experiences vary.
Ultimate 4From $53.96 with Subscribe & Save
Customer Reviews
Overall rating: 4.9 / 5 from 62 reviews.
I love the Ultimate 4, its given me loads more energy, reduced inflammation in lower back with little to no back ache. Has improved circulation to my whole body
I am now on my 3rd order of Boost 3, ultimate 4 and the Testosterone TRx. I have noticeably more energy, less joint pain and I’m sleeping a lot better. I still get the occasional night sweat but it’s no longer every night. And my sleep score is now regularly above 90. I am 54 and hitting menopause.
Jeff’s Ultimate 4 and Boost have been game changers for my husband and I. We’ve been on them both for a month and our energy levels have gone through the roof! I’ve been dancing through the day like a little kid. No need for caffeine anymore 🙏😊
Only been using Ultimate 4 for 10 days now and I do feel like I have more energy. The test strips started off almost white but happy to say they are now registering slightly pink which means it’s working Woo Hoo 🙌
I knew Jeff designed good products because years ago I relied on 30 plus for women, so when I saw he had nitric oxide, I had to try it. I’ve been using it for two weeks and I certainly have more energy and sleep better, the arthritis in my knee has changed. I will keep using it
I am amazed at how quickly my energy increased. I have been having B12 shots every 3mths for years with no real benefit.
Ultimate 4 helped after only a few days and it tastes great.
Taste great , levels increased within a week & could definitely feel the increase in energy , almost too much energy after 2 weeks on it, so I reduced my dose to every 3rd day
Love the Boost 3 & Ultimate 4 mixed together, it’s so refreshing. I look forward to it every day. I’m yet to see noticeable results of the Trx yet, but it’s only been a few weeks.
I’ve tried plenty of supplements over the years, but this is honestly the best I’ve taken!
I took it to Europe with me & noticed a difference almost immediately. I had more energy, felt amazing & didn’t get sick once during the trip.
When I got home, I ran out while waiting for my next order. After five days without it, I could really notice the difference in how I felt. I’m back on it now & so impressed I’m getting the whole family started!
Cannot recommend it enough. Six stars if I could!
Taking the ultimate 4 and boost 3 and have never felt better. Loads of energy and i have had no coldsore outbreaks at all. Hubby 's blood pressure has improved and has also noticed more energy 100% recommend these products
My husband and I are 70 and 64 respectively and whilst we are still building our NO levels due to our age and other health factors we are thrilled to be experiencing a great improvement in our energy levels. No longer hitting a brick wall mid afternoon is just fantastic. We feel we are getting the opportunity to age better!
Love it - definitely feeling more energised. Cant seem to get a good reading on the nitric test strips but I do feel better. I think i may need to add the boost to complement on my next order
My name is Sheryl Ogston I am 75 years old, my daughter Rochelle gave me the ultimate 4 and boost 3 for my birthday, I have been talking it for a month now. I am feeling great, more energy, brain fog better, just feeling better all round and my nitric oxide levels are up to 110mg/L. I have been telling everyone I know to get onto it. Thanks Jeff for such great products.
So far one tub and energy more consistent. Took overseas whilst conquering the streets of Japan! Definitely needed! Purchased my second tub and will test more with this one to check NO levels
I noticed a difference in my energy levels & the flow on effect was my mood, within days of starting this. I can’t wait to see the long term effects it has.
2nd tub just started and enjoying the taste and easy of mixing the drink of a morning.
Starting to feel my energy increasing. Sleeping better and not needing to hit the snooze button on my alarm 😄
Following Jeff's recommendations with diet and exercise and looking forward to feeling fantastic again
Whilst it is too early to show an increase in my nitric oxide readings as I’ve only been taking this product for a few weeks, I definitely have more energy and improved brain function.
I was taking the women’s bundle for a month. Felt the benefits almost immediately. Unfortunately due to postage, my recent order got lost. I didn’t have anything for 3 weeks. Extremely disappointed, but I just had to be patient. My order finally arrived a few days ago and hands down, the best feeling! I actually think in hindsight the few weeks without these amazing products actually proved to me how good they really are. I Feel AMAZING! Thank you Jeff…. Long may this last🙏🏻
Clear, honest answers. Still unsure? Take the free assessment and join the community.
One scoop (6 g) in water each morning, or 30 to 60 minutes before exercise.
Use the nitric oxide saliva strips. Test before you start and again after two to four weeks. Most people see the colour deepen.
Many people do, with their doctor monitoring. Speak with your healthcare provider before starting, as your medication may need reviewing.
Ultimate 4 contains L-citrulline, which raises arginine. It's not recommended if you're prone to cold sores, or if you're pregnant or breastfeeding.
You save 10% on every order and it arrives monthly. You can skip, change or cancel any time from your account. No lock-in.
Once you've ordered, log in to your account to read The Butterworth Protocols as a flipbook or download the PDF. The Nitric Oxide Kitchen eating guide is emailed to you.
Ultimate 4 is formulated to support the body's natural nitric oxide production, a key molecule involved in healthy circulation and vascular function. It supports blood vessel flexibility and cardiovascular wellbeing, making it ideal for those focused on heart health or wanting to proactively support their circulatory system.
Most users experience no side effects when using this product as directed. It is well tolerated in general use. Speaking with your healthcare professional is recommended before use, particularly if you are currently under medical supervision.
If you are currently taking prescribed medications, we recommend discussing supplementation with your healthcare professional before starting. They can monitor your progress and advise on what is appropriate for your individual circumstances.
The formula contains Arugula extract, L-citrulline, Ascorbic Acid, and Monk Fruit powder. All ingredients are sourced from trusted suppliers with no artificial additives or fillers.
Use 1 scoop per day mixed into water. It combines well with BOOST. Most users notice benefits within 2–4 weeks of consistent use.
Yes. You can choose a subscription at checkout for automatic monthly delivery and save on each order for individual products, or choose specific combinations on either 1 month or 2 month cycles. You can cancel anytime or adjust your subscription easily. If you have any issues simply contact our support team directly.
Yes, all our products are vegetarian and the capsules are vegecaps.
This depends on the type of fast and your goal. Most people actually practice time-restricted eating rather than true fasting. Any food restriction under 24 hours is time-restricted eating. The benefits of fasting beyond 24 to 72 hours come from autophagy, and the products will break this process. Beyond 72 hours this effect is reduced and it is advisable to take the products to support the detoxification process. Under 24 hours you can take the products as normal.
We currently ship globally. Our goal is to build an international community of healthy and vital people. We have capped shipping costs to make it more affordable.
Most orders arrive within 3–7 business days, depending on location. Remote areas may take slightly longer.
Yes. You'll receive a tracking link by email once your order ships.
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